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If parents with babies that struggle to gain weight, whether they take care of premature infants, full-term babies, or toddlers, don't know which formulas are high in calories or how to prepare one, they can neglect their babies’ nutritional needs, which can lead to underdevelopment and serious health problems for the little ones.
But don't worry if you have no idea what high-calorie formulas are.
Get ready to find recipes that tell you how to make high-calorie formulas, lists ranking the best powder, concentrate, and ready-to-feed formulas, and advice that helps you ensure your baby gains weight safely.
To put together everything you'll find in this article, we researched official medical guidelines, topic-related scientific articles, and, not lastly, the recommendations of different children’s hospitals and pediatric health authorities.
To increase your baby’s calorie intake, you can fortify breast milk or switch to high-calorie formula.
Before preparing breast milk or formula with a higher number of calories, however, you must consult your baby’s doctor and get his approval.
A high-calorie formula is a formula that has more than 20 calories per ounce (30 ml).
Most standard formulas, according to Children’s Minnesota’s formula adjustment guidelines, have 20 calories per ounce (30 ml). Yet, the guidelines claim that some babies need more than 20 calories/oz to grow.[1]
Children's Minnesota
See the formula adjustment guidelines recommended by Children's Minnesota.
Did you know? High-calorie formulas are the only beverages tailored for infants in the list of the best high-calorie drinks.
Learn below how to make different types of high-calorie formulas, whether you want to use breast milk, powder formula, or liquid concentrate formula.
If babies are breastfeeding, they can get more calories by having bottle feedings made of breast milk and powdered formula. The bottle feedings can replace breastfeeding sessions or be used as additional feedings between breast sittings.
Breast milk, according to clinical dietitian Lori S. Brizee from Seattle's Children's Hospital and Regional Medical Center, may be concentrated with a powdered formula to 24 calories per ounce (30 ml).[2]
Lori S. Brizee MS, RD, CD
Published for: University of Washington
See Lori Brizee's recommendations for increasing infant formula calories.
Yet, the Children’s Minnesota’s fortified breast milk guidelines offer instructions for concentrating breast milk up to 28 calories per ounce (30 ml).[3]
Children's Minnesota
See the guidelines recommended by Children's Minnesota for making fortified breast milk.
No matter how many calories your baby needs, we have you covered.
After simplifying and improving Children’s Minnesota’s instructions for making high-calorie fortified breast milk, we made an easy-to-follow recipe for enhancing breast milk that you can find below.[3]
Children's Minnesota
See the guidelines recommended by Children's Minnesota for making fortified breast milk.
Since you don’t want to feed your baby any harmful substances, you should always make sure you prepare fortified breast milk in a clean way.
Here are actions you can take to prevent feeding contamination:
The Dietary Guidelines for Americans (DGA) point out the importance of washing all infant feeding items, such as bottles and nipples, meticulously. Moreover, you should consider sanitizing feeding items, such as bottles, pump parts, and nipples, for:
Dietary Guidelines for Americans 2020-2025
Read the 2020-2025 edition of the Dietary Guidelines for Americans (PDF).
The best way to find out how many calories per ounce (30 ml) should your fortified breast milk have is to ask your baby’s dietitian.
If your baby needs a higher caloric intake, then you will be advised to make fortified breast milk that has one of the following caloric intakes, depending on your baby’s needs:
Once you know how many calories should the fortified breast milk have, you can go on and set how much breast milk and formula powder you need to make it.
To measure breast milk, use a liquid measuring cup. To ration powder, use standard measuring spoons or the scoop provided with the formula can.
See below how much breast milk and 20-calorie formula powder you need to make different types of high-calorie fortified breast milk.
Note: you can use either regular or premature formula to make high-calorie fortified breast milk.
To avoid clumping the formula powder, warm breast milk at room temperature or slightly above before mixing it with the powder.
To warm breast milk, put it in a bottle and place it in warm water.
The last step you need to follow before finishing the fortified breast milk is to mix the ingredients.
Put the formula powder in the bottle containing the warmed breast milk. Then, shake the bottle well until there is no visible powder left.
To increase the calories of infant formula, you need to rise its caloric density by using a higher percentage of formula powder compared to water in the preparation phase.
Starting from CDC’s advice on how to prepare powdered infant formula (PDF), we put together a recipe for making a high-calorie formula using powdered formula.[5]
Centers for Disease Control and Prevention (CDC)
Learn more about CDC's instructions for preparing powdered infant formula.
To make sure you can safely use the formula powder, check the expiration date on the can, and inspect the condition of the can. Usually, according to CDC, it’s not a good sign if the formula powder container has dents, puffy ends, or rust spots.
To keep your infant safe and healthy, always make formula in a clean environment.
Here are some precautions to take to avoid contamination:
Besides, according to the Dietary Guidelines for Americans, you should consider sanitizing feeding items, such as bottles, pump parts, and nipples, for the following types of infants:
Dietary Guidelines for Americans 2020-2025
Read the 2020-2025 edition of the Dietary Guidelines for Americans (PDF).
The best way to find out how many calories per ounce should your formula have is to ask your baby’s dietitian.
If your baby needs a higher caloric intake, then you will be advised to make a formula that has more than 20 calories per ounce (30 ml).
As a general rule backed up by CDC, when you prepare formula, you should use the specific amount of water and formula powder listed on the infant formula can.
In the case of preparing high-calorie formulas, however, you will rarely get instructions on the can.
Therefore, don’t try to adjust an infant formula on your own. Always get the baby’s dietitian’s approval beforehand because he is the most suitable person for giving ingredient ratio instructions regarding higher caloric intake.
Also, if you have children that are less than 1 year old, don’t add sugar, honey, or any other sweetener to breast milk or formula. Honey, according to the DGA, is especially harmful to babies under 1 year of age because it can cause botulism.[4]
Dietary Guidelines for Americans 2020-2025
Read the 2020-2025 edition of the Dietary Guidelines for Americans (PDF).
Below are the ratios of water and formula powder needed for different types of high-calorie formulas, as recommended in Children’s Minnesota’s powdered formula recipe chart (PDF).[1]
Children's Minnesota
Find the recipe chart for powdered formula recommended by Children's Minnesota.
CDC advises people to measure water first before adding the formula powder. Also, the authoritative medical body warns people to not dilute formula by adding extra water because it can be harmful for babies.
In formulas, use water only from safe sources.
Tap water, according to CDC, is generally a safe option. To make sure your tap water is safe, contact your local health department.
Moreover, if you use tap water to prepare formula, you should, according to Children’s Minnesota’s formula adjustment guide, allow the cold tap water to flow freely for 30-60 seconds before adding it the bottle to avoid the water sitting in the pipes.[1]
Children's Minnesota
See the formula adjustment guide made by Children's Minnesota.
A type of water that is not safe for children according to the Children’s Minnesota guidelines is well water because it might carry bacteria.
To measure the water, use a clear measuring cup for liquids. After you poured the water in it, put the cup on an even surface and check if the liquid is at the right level.
When it comes to measuring powder, you should use only the scoop provided in the formula can. Also, make sure to level the powder in the scoop.
Moreover, don’t replace the scoop with a tablespoon.
A tablespoon, according to a Washington study evaluating methods of making powdered formulas, is not an accurate measurement tool for preparing infant formulas, especially for infants with abnormal growth.[2]
Lori S. Brizee MS, RD, CD and Susan Casey RD, CD
Published by: University of Washington
See the study that evaluated traditional methods of preparing powdered formulas.
After you added the right ingredient ratio to a feeding bottle, you need to mix the water and the formula powder by shaking it, and not stirring it.
Shake until lumps are gone.
The next logical step after preparing the formula is feeding it to your baby.
You don’t need, according to CDC, to warm the bottle before feeding. Nevertheless, if you decide to do so, you can place the bottle under running warm water or into a bowl of warm water for a few minutes.
Keep in mind that the formula mustn’t be hot when you feed your infant. CDC recommends the wrist test to make sure of this: put a few drops on the inside of your wrist.
Warning: do not warm the formula in the microwave because it creates hot spots, which can be harmful for your baby’s mouth.
You can also make high-calorie formulas by combining water with liquid concentrate formulas.
Formulas made from liquid concentrate formulas, according to registered dietitians from Children's Hospital and Regional Medical Center in Washington, are the preferred choice if you need to be very precise with measurements.[2]
Lori S. Brizee MS, RD, CD and Susan Casey RD, CD
Published by: University of Washington
See the precise measurement recommendation from the Seattle Children's Hospital.
Below is a recipe, adapted from Children’s Minnesota’s formula adjustment guidelines, for preparing high-calorie formulas from liquid concentrate.[1]
Children's Minnesota
See the formula adjustment guidelines recommended by Children's Minnesota.
It can be easy to confound liquid concentrate formulas with ready-to-use formulas because they are both liquids.
Therefore, always make sure to check the formula label for the word “concentrate” and the absence of the phrase “ready to use”.
To keep your infant safe and healthy, always make formula in a clean environment.
Here are some precautions to take to avoid contamination:
Besides, according to the Dietary Guidelines for Americans, you should consider sanitizing feeding items, such as bottles, pump parts, and nipples, for the following types of infants:
Dietary Guidelines for Americans 2020-2025
Read the 2020-2025 edition of the Dietary Guidelines for Americans (PDF).
The best way to find out how many calories per ounce should your formula have is to ask your baby’s dietitian.
If your baby needs a higher caloric intake, then you will be advised to make a formula that has more than 20 calories per ounce (30 ml).
In the case of preparing high-calorie formulas, you will rarely get instructions on the can.
Therefore, don’t try to adjust an infant formula on your own. Always get the baby’s dietitian’s approval beforehand because he is the most suitable person for giving ingredient ratio instructions regarding higher caloric intake.
Also, if you have children that are less than 1 year old, don’t add sugar, honey, or any other sweetener to breast milk or formula. Honey, according to the DGA, is especially harmful to babies under 1 year of age because it can cause botulism.[4]
Dietary Guidelines for Americans 2020-2025
Read the 2020-2025 edition of the Dietary Guidelines for Americans (PDF).
Below are the ratios of water and liquid concentrate needed for different types of high-calorie formulas, as recommended in Children’s Minnesota’s liquid concentrate recipe chart (PDF).[1]
In formulas, use water only from safe sources.
Tap water, according to CDC, is generally a safe option. To make sure your tap water is safe, contact your local health department.
Moreover, if you use tap water to prepare formula, you should, according to Children’s Minnesota’s formula adjustment guide, allow the cold tap water to flow freely for 30-60 seconds before adding it the bottle to avoid the water sitting in the pipes.[1]
Children's Minnesota
See the formula adjustment guide made by Children's Minnesota.
A type of water that is not safe for children according to the Children’s Minnesota guidelines is well water because it might carry bacteria.
To measure the water, use a clear measuring cup for liquids. After you poured the water in it, put the cup on an even surface and check if the liquid is at the right level.
After shaking the liquid concentrate, open and pour it into a feeding bottle. Afterward, add the water in the liquid measuring cup over the concentrate.
After you added the right ingredient ratio to the feeding bottle, you need to mix the water and the liquid concentrate.
If you don’t have a large enough bottle to mix the ingredients in, you can use another type of clean container.
The next logical step after preparing the formula is feeding it to your baby.
You don’t need, according to CDC, to warm the bottle before feeding. Nevertheless, if you decide to do so, you can place the bottle under running warm water or into a bowl of warm water for a few minutes.
Keep in mind that the formula mustn’t be hot when you feed your infant. CDC recommends the wrist test to make sure of this: put a few drops on the inside of your wrist.
Warning: do not warm the formula in the microwave because it creates hot spots, which can be harmful for your baby’s mouth.
You can't make high-calorie formulas without picking a formula brand beforehand.
Generally, all formula brands, whether it’s Enfamil, Similac, or another one, have similar calories.
After all, to make a formula with a higher number of calories, you need, as we learned earlier in this article, to adjust the ingredient ratio.
Some of the most popular brands you can use to follow high-calorie formula recipes are Enfamil, Similac, Nutramigen, Infatrini, SMA, and Gerber.
Below is a selection of the most popular powder and liquid concentrate formula brands that you can use to prepare high-calorie formula recipes for your babies, whether they are premature, full-term, or already toddlers.
Process of selecting the formula brands
We selected the formulas after checking official medical recommendations, the lists of best-rated formulas on Amazon and Walmart, and the most searched formulas online.
The formulas were chosen objectively. Unfold Today does not receive any commission if you buy any of the formulas listed in this article.
Enfamil
Learn more about Enfamil NeuroPro EnfaCare formula powder.[6]
The Enfamil NeuroPro Enfacare powder formula is recommended in the Maine WIC program.[7]
Maine's governmental website
Learn more about the high-calorie formula brands recommended in the Maine WIC program.
Similac
Learn more about the Similac NeoSure powder formula.[8]
The Similac Neosure powder formula is recommended in the Maine WIC program.[7]
Maine's governmental website
Learn more about the high-calorie formula brands recommended in the Maine WIC program.
SMA Nutrition
Learn more about the SMA Gold Prem 2 formula.[9]
The SMA formulas are quite popular since they are frequently searched on Google.
Enfamil
Learn more about the Enfamil NeuroPro Infant Formula powder.[6]
The Enfamil NeuroPro Infant Formula counts among the best-rated formulas on Amazon.
Enfamil
Learn more about the Enfamil NeuroPro Gentlease Infant Formula powder.[6]
The Enfamil NeuroPro Gentlease Infant Formula counts among the best-rated formulas on Amazon.
Similac
Learn more about the Similac Pro-Advance Infant powder formula.[8]
The Similac Pro-Advance Infant Formula counts among the best-rated formulas on Amazon.
Gerber
Learn more about the Gerber Good Start SoothePro Infant Formula powder.[10]
The Gerber Good Start SoothePro Infant Formula counts among the best-rated formulas on Amazon.
Gerber
Learn more about the Gerber Good Start GentlePro Infant Formula powder.[10]
The Gerber Good Start GentlePro Infant Formula counts among the best-rated formulas on Amazon.
Enfamil
Learn more about the Nutramigen with Probiotic LGG Hypoallergenic Infant Formula powder.[6]
The Nutramigen Hypoallergenic Powder Infant Formula with Probiotic LGG counts among the best-rated formulas on Amazon.
Enfamil
Learn more about the Enfamil Concentrated Liquid Infant Formula via Walmart.[11]
The Enfamil Concentrated Liquid Infant Formula counts among the best-rated formulas at Walmart.
Enfamil
Learn more about the Nutramigen Hypoallergenic Liquid Infant Formula Concentrate via Enfamil.[6]
The Nutramigen Hypoallergenic Liquid Infant Formula Concentrate counts among the best-rated formulas at Walmart.
Abbot Nutrition's Store
Learn more about the Similac Advance Infant Formula Concentrated Liquid via the Abbott Store.[12]
The Similac Advance Infant Formula Concentrated Liquid counts among the best-rated formulas at Walmart.
Enfamil
Learn more about the Enfagrow PREMIUM Gentlease Toddler Powder.[6]
The Enfagrow PREMIUM Gentlease Toddler Powder counts among the best-rated formulas on Amazon.
Earth's Best
Learn more about the Earth's Best Organic Toddler Milk Drink Powder.[13]
The Earth's Best Organic Toddler Milk Drink Powder counts among the best-rated formulas on Amazon.
Nature's One
Learn more about the Baby's Only Organic Premium Dairy Toddler Formula via Nature's One.[14]
The Baby's Only Organic Premium Dairy Toddler Formula counts among the best-rated formulas on Amazon.
Nature's One
Learn more about the Baby's Only Organic Sensitive Toddler Formula via Nature's One.[14]
The Baby's Only Organic Sensitive Toddler Formula counts among the best-rated formulas on Amazon.
Gerber
Learn more about the Nestle Nan Pro Toddler Drink Powder via Gerber.[10]
The Nestle NAN Pro Toddler Drink Powder counts among the best-rated formulas on Amazon.
Gerber
Learn more about the Gerber Good Start Grow Nutritious Toddler Drink Powder.[10]
The Gerber Good Start Grow Nutritious Toddler Drink Powder counts among the best-rated formulas at Walmart.
Abbot Nutrition
Learn more about the Similac Go and Grow Toddler Drink via Abbott Nutrition.[15]
The Similac Go and Grow Toddler Drink counts among the best-rated formulas at Walmart.
SMA Nutrition
Learn more about the SMA ADVANCED Growing Up Milk.[9]
The SMA formulas are quite popular since they are frequently searched for on Google.
You can skip the hassle of preparing high-calorie formulas at home by investing in ready-to-feed high-calorie formulas.
Yet, you need to get your baby’s doctor's approval before feeding your baby ready-to-use formulas.
High-calorie ready-to-feed infant formulas have over 20 calories per ounce (30 ml).
Below is a selection of some of the most popular ready-to-feed formula brands that you can use to feed your babies, whether they are premature, full-term, or already toddlers.
Process of choosing the formula brands
We selected the formulas after checking official medical recommendations, the lists of best-rated formulas on Amazon and Walmart, and the most searched formulas online.
The formulas were chosen objectively. Unfold Today does not receive any commission if you buy any of the formulas listed in this article.
Nutricia
Learn more about the Infatrini ready-to-use formula via Nutricia.[16]
Calories: 30 per 1 fl oz (30 ml)
The Infatrini formula is recommended by UK's National Health Service (NHS).[17]
UK National Health Service
Find out some of the high-energy nutritional formulas recommended by the NHS.
Abbot Nutrition UK
Learn more about the Similac High Energy formula via Abbott Nutrition.[18]
Calories: 30 per 1 fl oz (30 ml)
The Similac High-Energy formula is recommended by UK's National Health Service (NHS).[17]
UK National Health Service
Find out some of the high-energy nutritional formulas recommended by the NHS.
Enfamil
Learn more about the Enfamil Premature Infant Formula 24 Calorie with Iron.[6]
Calories: 24 per 1 fl oz (30 ml)
The Enfamil Premature 24 Calorie Infant Formula is recommended in the Maine WIC program.[7]
Maine's governmental website
Learn more about the high-calorie formula brands recommended in the Maine WIC program.
SMA Nutrition
Learn more about the SMA Gold Prem 1 formula.[9]
Calories: 24 per 1 fl oz (30 ml)
The SMA formulas are quite popular since they are frequently searched for on Google.
Enfamil
Learn more about the Enfamil NeuroPro EnfaCare Liquid.[6]
Calories: 22 per 1 fl oz (30 ml)
The Enfamil NeuroPro EnfaCare Liquid Formula is recommended in the Maine WIC program.[7]
Maine's governmental website
Learn more about the high-calorie formula brands recommended in the Maine WIC program.
Similac
Learn more about the Similac NeoSure Ready-to-Feed formula.[8]
Calories: 22 per 1 fl oz (30 ml)
The Similac NeoSure Ready-to-Feed Formula is recommended in the Maine WIC program.[7]
Maine's governmental website
Learn more about the high-calorie formula brands recommended in the Maine WIC program.
Nutricia
Learn more about the Infatrini ready-to-use formula via Nutricia.[16]
Calories: 30 per 1 fl oz (30 ml)
The Infatrini formula is recommended by UK's National Health Service (NHS).[17]
UK National Health Service
Find out some of the high-energy nutritional formulas recommended by the NHS.
Abbot Nutrition UK
Learn more about the Similac High Energy formula via Abbott Nutrition.[18]
Calories: 30 per 1 fl oz (30 ml)
The Similac High-Energy formula is recommended by UK's National Health Service (NHS).[17]
UK National Health Service
Find out some of the high-energy nutritional formulas recommended by the NHS.
Similac
Learn more about the Similac Alimentum Hypoallergenic Ready-to-Feed Infant Formula.[8]
Calories: 30 per 1 fl oz (30 ml)
The Similac Alimentum Hypoallergenic Ready-to-Feed formula counts among the best-rated formulas on Amazon.
Enfamil
Learn more about the Enfamil NeuroPro Infant Formula Liquid.[6]
Calories: 30 per 1 fl oz (30 ml)
The Enfamil NeuroPro Infant Formula Liquid counts among the best-rated formulas on Amazon.
Enfamil
Learn more about the Enfamil 24 Calorie Infant Liquid Formula.[6]
Calories: 24 per 1 fl oz (30 ml)
The Enfamil 24 Calorie Infant Liquid Formula is recommended in the Maine WIC program.[7]
Maine's governmental website
Learn more about the high-calorie formula brands recommended in the Maine WIC program.
Nutricia
Learn more about the Infatrini ready-to-use formula via Nutricia.[16]
Calories: 100 per 3.4 fl oz (100 ml)
The Infatrini formula is recommended by UK's National Health Service (NHS).[17]
UK National Health Service
Find out some of the high-energy nutritional formulas recommended by the NHS.
Abbot Nutrition UK
Learn more about the Similac High Energy formula via Abbott Nutrition.[18]
Calories: 100 per 3.4 fl oz (100 ml)
The Similac High-Energy formula is recommended by UK's National Health Service (NHS).[17]
UK National Health Service
Find out some of the high-energy nutritional formulas recommended by the NHS.
Enfamil
Learn more about the Enfagrow NeuroPro Toddler Nutritional Drink.[6]
Calories: 67 per 3.4 fl oz (100 ml)
The Enfagrow NeuroPro Toddler Nutritional Drink counts among the best-rated formulas at Walmart.
Human milk is the healthiest feeding option for babies in the first months of their lives while fortified and normal formulas are the next best choices. Yet, human milk should be replaced by high-calorie formulas when a baby has increased caloric needs.
Infant formula, according to a 2022 study on the effects of formula feeding on premature infants, is a good secondary option to human milk because it has more calories and proteins.[19]
Children (Basel) journal
Made at: Universidade de Vigo and University of Leon
See the study about the effects of feeding formula milk to premature infants.
Replacing human milk with formula is a common practice in the USA.
Only 1 in 4 American babies, according to CDC’s 2022 Breastfeeding Report, were fed only human milk until age 6 months. Therefore, 75% of Americans give their babies formula, standard or high-calorie.[20]
Centers for Disease Control and Prevention (CDC)
Check out CDC's breastfeeding report card for 2022.
Below is a list of babies that are usually recommended high-calorie formulas:
Premature (immature) and ill infants, according to a scientific review about enhanced-calorie formulas, need a high caloric intake to achieve their growth goals.[21]
Neonatal Network
See the study exploring different considerations and options of enhanced-calorie formulas.
Conveniently, premature infants, according to a NY University School of Medicine study about the effects of high-calorie feedings on premature infants, increase their weight successfully if they are fed high-calorie formulas.[22]
The Journal of Pediatrics
Made at: New York University School of Medicine
See the study about effects of high-calorie feedings on the growth of premature infants.
Besides aiding premature infants, a higher caloric intake, as stated in a pediatric study on the relationship between formula concentration and infant growth, helps infants with normal size gain weight.[23]
The Journal of Nutrition
Made at: University of Iowa
See the study exploring the relationship between formula concentration and the rate of growth of normal infants.
Furthermore, high-calorie formulas, according to a clinical trial comparing the effects of standard formulas to the ones of high-calorie formulas on methadone-exposed infants, may be beneficial for babies with prenatal methadone exposure.[24]
Hospital Pediatrics
See the study comparing standard and high-calorie formulas for methadone-exposed infants.
The DGA recommends people to feed infants only human milk until they're 6 months old and keep breast milk a part of their diet until they're at least 1 year old. Yet, if human milk is unavailable, you should feed iron-fortified infant formula to infants during their 1st year of life.[4]
Dietary Guidelines for Americans 2020-2025
Read the 2020-2025 edition of the Dietary Guidelines for Americans (PDF).
High-calorie formulas are the only weight-gain foods people can feed their babies with until the little ones are 6 months old.
Whether you feed babies human milk or formula, introduce them to nutrient-dense foods that will enrich their diet when they are about 6 months old. Once your infant gets to 1 year old and becomes a toddler, he won’t need formula anymore, according to the DGA.[4]
Dietary Guidelines for Americans 2020-2025
Read the 2020-2025 edition of the Dietary Guidelines for Americans (PDF).
Since a 12-month-old baby should already be accommodated with a variety of food groups, flavors, and textures, he should be able to get all the nutrients he needs from age-appropriate foods and beverages other than formulas.
Therefore, toddler milk, drinks, and formulas, according to CDC’s guide for choosing an infant formula, are not needed to meet nutritional goals because they typically have added sugars and can be replaced by plain whole cow milk or fortified unsweetened soy beverage.[25]
Centers for Disease Control and Prevention (CDC)
Learn more about CDC's instructions for choosing an infant formula.
Although they can help a baby gain weight, high-calorie formulas need to be fed carefully to avoid side effects.
A few of the known side effects babies can suffer from after ingesting high-calorie formula are dehydration and constipation.
The high-calorie formulas that are considered safe, according to the Washington-based Children’s Hospital and Regional Medical Center, have up to 24 calories/oz (0.8 calories/ml). If you feed your baby formula with over 24 calories/oz, monitor the baby closely because he may get dehydrated.[2]
Lori S. Brizee MS, RD, CD
Published for: University of Washington
See Lori Brizee's recommendations for keeping high-calorie formulas safe.
Besides dehydration, high-calorie formulas may cause constipation.
Constipation in babies, according to the National Health Service’s advice on constipation, commonly appears when they first consume infant formula because formulas are harder to digest than breast milk, and their little bodies need to adapt to digesting new foods.[26]
UK National Health Service (NHS)
See the NHS guide for dealing with constipation and bottle feeding.
To avoid side effects, feed your baby a formula that is higher in calories only if the baby’s doctor, be it a pediatrician or baby nutritionist, gives you a prescription. Otherwise, your baby might show signs of side effects or develop other health problems.
But, even if you have the doctor’s prescription, you still need to monitor the baby.
Here are a few reasons for contacting your baby’s medical provider:
When your baby starts gaining weight without any problems, you can expect to be guided toward a normal formula.
The Dietary Guidelines for Americans emphasize the importance of storing both human milk and infant formula safely.[4]
Dietary Guidelines for Americans 2020-2025
Read the 2020-2025 edition of the Dietary Guidelines for Americans (PDF).
Baby formula made from powder, according to Children’s Minnesota’s formula adjustment guidelines, can safely be kept in a covered container in the refrigerator for a maximum of 24 hours.[1]
Children's Minnesota
See the formula adjustment guidelines recommended by Children's Minnesota.
Yet, according to CDC’s instructions for storing powdered infant formula, you should get rid of the formula if you already fed your baby with it, or if you haven’t refrigerated the formula within 2 hours after preparing it. In case you act otherwise, you risk feeding the baby with bacteria-contaminated leftovers.[5]
Centers for Disease Control and Prevention (CDC)
Regarding the formula powder itself, you can keep it 1 month after opening the can.
When it comes to formulas made from liquid concentrate, according to Children’s Minnesota’s formula guidelines for liquid concentrate, they can be kept in the refrigerator for a maximum of 48 hours. Make sure, however, to check the information on the formula can as well.[1]
Children's Minnesota
Check out liquid concentrate formula adjustment guidelines offered by Children's Minnesota.
According to the Dietary Guidelines for Americans, human milk should be fed to the baby within 2 hours of expressing it.[4]
Dietary Guidelines for Americans 2020-2025
Read the 2020-2025 edition of the Dietary Guidelines for Americans (PDF).
Alternatively, according to CDC’s breast milk storage instructions, you can refrigerate fresh human milk within 4 hours of preparing it for up to 4 days. But, if you thaw previously frozen human milk, you should use it within 24 hours and not refreeze it again.[27]
Centers for Disease Control and Prevention (CDC)
Check out CDC's instructions for storing breast milk.
To warm human milk safely, place it in warm water and never put it in the microwave.
If you are looking to make a high-calorie formula with 22, 24, or more calories per ounce (30 ml) using a specific brand, like Enfamil, Similac, or Nutramigen, you should follow the recipes officially recommended for the kind of formula you want to use (powder or liquid concentrate), or pick a ready-to-feed formula.
No matter what brand you pick, you should, however, get approval and potential additional instructions from your baby’s doctor before feeding the formula.
Since a formula with 30 calories per ounce (30 ml) is one of the formulas with the most calories, it doesn’t have an easily reachable recipe. Yet, if you found out your baby needs a formula with so many nutrients, you should ask your baby’s dietitian for instructions on how to prepare it.
Alternatively, you can get a ready-to-feed 30-calorie formula and skip the hassle of preparing it.
To sum up, high-calorie formulas are formulas with more than 20 calories per ounce (30 ml) that can be made at home using formula powder (or liquid concentrate) combined with human milk or water by following medically-approved recipes, or bought from stores in ready-to-feed form.
You can find formula brands, like Enfamil and Similac, created for different types of babies, whether they are premature babies (preemies), full-term babies, or toddlers.
Baby dietitians usually recommend high-calorie formulas to help premature infants, babies with health or growth problems, ill infants, or babies exposed to prenatal drugs to gain weight.
Yet, high-calorie formulas should be consumed only with the approval of your baby’s pediatrician or dietitian because they can trigger side effects, like dehydration and constipation.
In the end, with the right approach, high-calorie formulas can help your baby gain weight in a safe and healthy way.
Unfold Today has rigorous sourcing principles adhering to the top journalistic standards, so our writers always look for official, experienced, and first-hand sources. Read more about how we keep our content trustworthy and updated by reading our editorial process.
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